Neurotoxicity is a dose-limiting side effect of many different agents used in chemotherapy treatments; in particular, platinum drugs, including oxaliplatin, are associated with neurotoxicity. Oxaliplatin is an integral part of chemotherapy for colorectal cancer (CRC) in the adjuvant and metastatic setting. However, neurotoxicity is a dose-limiting side effect of this agent, limiting its use in select patients. The incidence of oxaliplatin-associated neurotoxicity has been estimated to be 82% to 92% (all grades), with 7% to 19% grade 3.¹ The unique presentation of oxaliplatin-induced neurotoxicity can make it a challenge for oncology nurses to manage. Oxaliplatin can cause acute and cumulative neurotoxicity, with cumulative toxicity serving as the dose-limiting effect.

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Skin rash associated with HER1/EGFR therapy is generally considered mild to moderate in nature,1,2 affecting more than 50% of patients receiving treatment. The incidence of severe rash (grade 3) is reported in 16% to 18% of patients.2,3 The cutaneous eruptions appear primarily on the face, neck, and upper torso, as seen in Figure 1, and the face is often the first area affected by the rash.4

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Human sexuality is a broad term that encompasses sex, gender, identities and roles, sexual orientation, eroticism, pleasure, intimacy, and reproduction.1 Our views on sexuality are influenced by cultural, social, ethnic, and religious/spiritual beliefs and practices. These views may change throughout our lifetime and life experiences.

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